Additive manufacturing (AM) technology enables the possibility of realizing highly efficient, optimized structural components with configurations not achievable using conventional manufacturing methods. The Altair and Solid Thinking toolsets provide advanced capabilities to design structural topologies to minimize weight and maximize other performance criteria. However, conventional manufacturing processes require application of design constraints, such as directional access for machining, in the optimization that limit the structural efficiency of the resulting design. AM can remove many of these constraints to allow for more efficient configurations under the applied loading conditions. Case studies show the potential to reduce weight up to 30% for components with applied bending and torsional loads by allowing increased complexity configurations that could only be manufactured additively.